Pillar[5]arene-Based Glycoclusters: Synthesis and Multivalent Binding to Pathogenic Bacterial Lectins.
Chemistry
; 22(9): 2955-63, 2016 Feb 24.
Article
em En
| MEDLINE
| ID: mdl-26845383
ABSTRACT
The synthesis of pillar[5]arene-based glycoclusters has been readily achieved by CuAAC conjugations of azido- and alkyne-functionalized precursors. The lectin binding properties of the resulting glycosylated multivalent ligands have been studied by at least two complementary techniques to provide a good understanding. Three lectins were selected from bacterial pathogens based on their potential therapeutic applications as anti-adhesives, namely LecA and LecB from Pseudomonas aeruginosa and BambL from Burkholderia ambifaria. As a general trend, multivalency improved the binding to lectins and a higher affinity can be obtained by increasing to a certain limit the length of the spacer arm between the carbohydrate subunits and the central macrocyclic core.
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Assunto principal:
Pseudomonas aeruginosa
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Proteínas de Bactérias
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Glicoconjugados
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Compostos de Amônio Quaternário
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Lectinas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article