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Eliciting parental support for the use of newborn blood spots for pediatric research.
Yeung, Edwina H; Louis, Germaine Buck; Lawrence, David; Kannan, Kurunthachalam; McLain, Alexander C; Caggana, Michele; Druschel, Charlotte; Bell, Erin.
Afiliação
  • Yeung EH; Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, 7B03, Rockville, MD, 20852, USA. yeungedw@mail.nih.gov.
  • Louis GB; Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, 7B03, Rockville, MD, 20852, USA.
  • Lawrence D; Laboratory of Immunology, Wadsworth Center, Center for Medical Science, Albany, NY, 12203, USA.
  • Kannan K; Department of Environmental Health Sciences, University at Albany School of Public Health, Albany, USA.
  • McLain AC; Laboratory of Organic Analytical Chemistry, Wadsworth Center, New York State Department of Health, Albany, NY, 12203, USA.
  • Caggana M; Department of Environmental Health Sciences, University at Albany School of Public Health, Albany, USA.
  • Druschel C; Department of Epidemiology and Biostatistics, Arnold School of Public Health, Columbia, SC, USA.
  • Bell E; Laboratory of Human Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, 12203, USA.
BMC Med Res Methodol ; 16: 14, 2016 Feb 04.
Article em En | MEDLINE | ID: mdl-26846420
BACKGROUND: Biomarkers of exposures such as infection or environmental chemicals can be measured in small volumes of blood extracted from newborn dried blood spots (DBS) underscoring their potential utility for population-based research. However, few studies have evaluated the feasibility and utility of this resource; particularly the factors associated with parental consent, and the ability to retrieve banked samples with sufficient remaining volume for epidemiologic research. METHODS: At 8 months postpartum, 5,034 mothers of infants born (2008-2010) in New York (57 counties excluding New York City) were asked to consent for the use of residual DBS for the quantification of cytokines and environmental chemicals. Mothers were part of the Upstate KIDS study, a longitudinal birth cohort designed to evaluate child development through 3 years of age. Information on parental and infant characteristics was obtained from birth certificates and maternal report at 4 months postpartum. Multivariate logistic regression was used to identify factors associated with parental consent and with successful retrieval of DBS. RESULTS: Sixty-two percent (n = 3125) of parents consented. Factors significantly associated with consent included non-Hispanic ethnicity (odds ratio 2.04; 95% CI: 1.43-2.94), parity (1.29; 1.05-1.57), maternal obesity (1.42; 1.11-1.80) and reported alcohol use during pregnancy (1.51; 1.12-2.06). However, these associations corresponded to small absolute differences in proportions (4 to 8%), suggesting that the two groups remained comparable. Infant characteristics such as preterm delivery did not significantly differ by consent status among singletons and only ventilator use (OR 2.39; 95% CI: 1.06-5.41) remained borderline significant among twins in adjusted analyses. Among consented infants, 99% had at least one 3.2 mm punch successfully retrieved for biomarker analyses and 84% had a full DBS circle available. CONCLUSION: Parental characteristics varied slightly by consent, and the availability of samples for research purposes was high, demonstrating the feasibility of this resource for population based research.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise Química do Sangue / Consentimento dos Pais / Teste em Amostras de Sangue Seco / Mães Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Newborn Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise Química do Sangue / Consentimento dos Pais / Teste em Amostras de Sangue Seco / Mães Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Newborn Idioma: En Ano de publicação: 2016 Tipo de documento: Article