Allene Functionalized Azobenzene Linker Enables Rapid and Light-Responsive Peptide Macrocyclization.
Bioconjug Chem
; 27(3): 509-14, 2016 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-26849798
ABSTRACT
In this manuscript, we describe the efficient synthesis of a bis(allenamide) functionalized water-soluble azobenzene reagent (BSBDA) and its application as a new tool for the rapid generation of visible light-responsive macrocyclic peptides and peptide libraries displayed on the surface of bacteriophage. The allenamide functionality promotes cysteine ligation in model peptides and those displayed on phage with rates 2-3 orders of magnitude faster than the established alkyl halide containing azobenzenes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Compostos Azo
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Compostos Macrocíclicos
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Luz
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article