Removal of Dolutegravir by Hemodialysis in HIV-Infected Patients with End-Stage Renal Disease.
Antimicrob Agents Chemother
; 60(4): 2564-6, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26856824
ABSTRACT
Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting. (This study is registered at ClinicalTrials.gov under registration number NCT02487706.).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Soluções para Diálise
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Infecções por HIV
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Diálise Renal
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Fármacos Anti-HIV
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Compostos Heterocíclicos com 3 Anéis
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Falência Renal Crônica
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article