Association between breast milk fatty acids and HIV-1 transmission through breastfeeding.
Prostaglandins Leukot Essent Fatty Acids
; 105: 35-42, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26869089
ABSTRACT
A residual mother-to-child transmission of HIV through breastfeeding persists despite prophylaxis. We identified breast milk fatty acids (FA) associated with postnatal HIV transmission through breastfeeding in a case-control study. Cases (n=23) were HIV-infected women with an infant who acquired HIV after 6 weeks of age. Controls (n=23) were matched on infant׳s age at sample collection. Adjusting for maternal antenatal plasma CD4 T cell count, cis-vaccenic acid (181n-7) and eicosatrienoic acid (203n-3) were associated with HIV transmission in opposite dose-response manner OR (tertile 3 versus tertile 1) 10.8 and 0.16, p for trend=0.02 and 0.03, respectively. These fatty acids correlated with HIV RNA load, T helper-1 related cytokines, IL15, IP10, and ß2 microglobulin, positively for cis-vaccenic acid, negatively for eicosatrienoic acid. These results suggested a change in FA synthesis by mammary gland cells leading to increased cis-vaccenic acid in milk of mothers who transmitted HIV to their infant during breastfeeding.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aleitamento Materno
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Infecções por HIV
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Ácidos Graxos
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Leite Humano
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Newborn
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article