Methylation, Glucuronidation, and Sulfonation of Daphnetin in Human Hepatic Preparations In Vitro: Metabolic Profiling, Pathway Comparison, and Bioactivity Analysis.

Liang, Si-Cheng; Xia, Yang-Liu; Hou, Jie; Ge, Guang-Bo; Zhang, Jiang-Wei; He, Yu-Qi; Wang, Jia-Yue; Qi, Xiao-Yi; Yang, Ling

Liang, Si-Cheng; Xia, Yang-Liu; Hou, Jie; Ge, Guang-Bo; Zhang, Jiang-Wei; He, Yu-Qi; Wang, Jia-Yue; Qi, Xiao-Yi; Yang, Ling.

Afiliação

Liang SC; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China; Second Affiliated Hospital of Dalian Medical University, Dalian, China; University of Chinese Academy of Sciences, Beijing, China.
Xia YL; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China; Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Hou J; Dalian Medical University, Dalian, China.
Ge GB; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. Electronic address: geguangbo@dicp.ac.cn.
Zhang JW; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
He YQ; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Wang JY; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China; Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Qi XY; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China; Second Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address: 7xiao1@163.com.
Yang L; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

J Pharm Sci ; 105(2): 808-816, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26869431

Assuntos

Glucuronídeos/metabolismo; Hepatócitos/metabolismo; Redes e Vias Metabólicas/fisiologia; Metaboloma/fisiologia; Sulfatos/metabolismo; Umbeliferonas/metabolismo; Células Cultivadas; Relação Dose-Resposta a Droga; Hepatócitos/efeitos dos fármacos; Humanos; Redes e Vias Metabólicas/efeitos dos fármacos; Metaboloma/efeitos dos fármacos; Metilação; Microssomos Hepáticos/efeitos dos fármacos; Microssomos Hepáticos/metabolismo; Umbeliferonas/farmacologia

Palavras-chave

8-O-methyldaphnetin; anti-inflammatory activity; daphnetin; glucuronidation; methylation; sulfonation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfatos / Umbeliferonas / Glucuronídeos / Hepatócitos / Redes e Vias Metabólicas / Metaboloma Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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