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Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [11 C]T-773 in nonhuman primates.
Takano, Akihiro; Stepanov, Vladimir; Nakao, Ryuji; Amini, Nahid; Gulyás, Balázs; Kimura, Haruhide; Halldin, Christer.
Afiliação
  • Takano A; Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
  • Stepanov V; Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
  • Nakao R; Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
  • Amini N; Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
  • Gulyás B; Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
  • Kimura H; Pharmaceutical Research Division, CNS Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Fujisawa, Japan.
  • Halldin C; Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
Synapse ; 70(6): 253-63, 2016 Jun.
Article em En | MEDLINE | ID: mdl-26878349
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Pirazóis / Piridazinas / Encéfalo / Distribuição Tecidual / Diester Fosfórico Hidrolases / Tomografia por Emissão de Pósitrons Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Pirazóis / Piridazinas / Encéfalo / Distribuição Tecidual / Diester Fosfórico Hidrolases / Tomografia por Emissão de Pósitrons Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article