G-quadruplexes and helicases.
Nucleic Acids Res
; 44(5): 1989-2006, 2016 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-26883636
ABSTRACT
Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures. The first indication of how G-quadruplex structures could be unfolded enzymatically came in the late 1990s with reports that some well-known duplex DNA helicases resolved these structures in vitro. Since then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly increased. The present review aims to present a general overview of the helicase/G-quadruplex field.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Helicases
/
Fatores de Transcrição de Zíper de Leucina Básica
/
Proteínas de Grupos de Complementação da Anemia de Fanconi
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Exodesoxirribonucleases
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RecQ Helicases
/
Quadruplex G
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article