Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains.

Rich, Megan C; Keene, Chesleigh N; Neher, Miriam D; Johnson, Krista; Yu, Zhao-Xue; Ganivet, Antoine; Holers, V Michael; Stahel, Philip F

Rich, Megan C; Keene, Chesleigh N; Neher, Miriam D; Johnson, Krista; Yu, Zhao-Xue; Ganivet, Antoine; Holers, V Michael; Stahel, Philip F.

Afiliação

Rich MC; Department of Orthopaedic Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, CO 80204, USA.
Keene CN; Department of Orthopaedic Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, CO 80204, USA.
Neher MD; Department of Orthopaedic Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, CO 80204, USA.
Johnson K; Alexion Pharmaceuticals, Cheshire, CT 06410, USA.
Yu ZX; Alexion Pharmaceuticals, Cheshire, CT 06410, USA.
Ganivet A; Department of Orthopaedic Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, CO 80204, USA.
Holers VM; Department of Medicine and Department of Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Stahel PF; Department of Orthopaedic Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, CO 80204, USA; Department of Neurosurgery, University of Colorado School of Medicine, Denver, CO 80204, USA. Electronic address: philip.stahel@dhha.org.

Neurosci Lett ; 617: 188-94, 2016 Mar 23.

Article em En | MEDLINE | ID: mdl-26892188

Assuntos

Inativadores do Complemento/uso terapêutico; Traumatismos Cranianos Fechados/tratamento farmacológico; Fármacos Neuroprotetores/uso terapêutico; Proteínas Recombinantes de Fusão/uso terapêutico; Animais; Encéfalo/efeitos dos fármacos; Encéfalo/metabolismo; Encéfalo/patologia; Morte Celular; Complemento C3/metabolismo; Traumatismos Cranianos Fechados/metabolismo; Traumatismos Cranianos Fechados/patologia; Masculino; Camundongos Endogâmicos C57BL; Microglia/metabolismo; Neurônios/patologia

Palavras-chave

CR2-conjugated pharmacological compounds; Neuroinflammation; Secondary brain injury; Site-targeted complement inhibition; Traumatic brain injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Traumatismos Cranianos Fechados / Fármacos Neuroprotetores / Inativadores do Complemento Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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