Effects of oral exposure to silver nanoparticles on the sperm of rats.
Reprod Toxicol
; 60: 133-9, 2016 04.
Article
em En
| MEDLINE
| ID: mdl-26900051
ABSTRACT
It has been demonstrated that exposure to silver nanoparticles (AgNPs) can induce toxicological effects in rodents. In this study, we investigated whether sub-chronic oral exposure to different doses of polyvinil pyrrolidone (PVP)-coated AgNPs (PVP-AgNPs) (50, 100 and 200mg/kg/day) could induce harmful effects on epididymal sperm rat parameters. Sperm motility, viability and morphology were examined. Moreover, a histological evaluation of testis and epididymis was also performed. High doses of PVP-AgNPs showed higher sperm morphology abnormalities, while a progressive, but not significant effect, was observed in other sperm parameters. The current results suggest that oral sub-chronic exposure to PVP-AgNPs induces slight toxicological effects in sperm rat parameters.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prata
/
Espermatozoides
/
Povidona
/
Nanopartículas Metálicas
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article