Targeting Fibronectin To Disrupt In Vivo Candida albicans Biofilms.
Antimicrob Agents Chemother
; 60(5): 3152-5, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-26902759
ABSTRACT
New drug targets are of great interest for the treatment of fungal biofilms, which are routinely resistant to antifungal therapies. We theorized that the interaction of Candida albicans with matricellular host proteins would provide a novel target. Here, we show that an inhibitory protein (FUD) targeting Candida-fibronectin interactions disrupts biofilm formation in vitro and in vivo in a rat venous catheter model. The peptide appears to act by blocking the surface adhesion of Candida, halting biofilm formation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candida albicans
/
Fibronectinas
/
Biofilmes
/
Antifúngicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article