Dydrogesterone support following assisted reproductive technique (ART) reduces the risk of pre-eclampsia.
Horm Mol Biol Clin Investig
; 27(3): 93-6, 2016 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-26910749
ABSTRACT
BACKGROUND:
Pre-eclampsia (PE) contributes to poor maternal morbidity and mortality. Progesterone is hypothesised to reduce the risk of PE.AIM:
To determine the effect of progestogen supplementation during assisted reproductive technique (ART) in reducing the incidence of PE.METHOD:
A retrospective comparative analysis among 1140 pregnancies between January 2006 and March 2015 conducted in a tertiary centre. A total of 570 pregnancies who conceived following ART with progesterone supplementation (study group) and an age-matched spontaneous pregnancies, without progesterone supplementation (control group, n=570) were included in the analysis. The study group received progesterone support following ART or intrauterine insemination (IUI) until 14-16 weeks' gestation.RESULTS:
The rate of PE was significantly lower in the study group compared to control group (8.4% vs. 14.2%, p<0.05). Women supplemented with dydrogesterone only showed a lower PE incidence as compared to women received a combination of dydrogesterone and hydroxyprogesterone caproate, however, it was not statistically significant (6.9% vs. 9.9%; 6.9%; p=0.2).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Progestinas
/
Técnicas de Reprodução Assistida
/
Didrogesterona
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article