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Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.
Shimshek, Derya R; Jacobson, Laura H; Kolly, Carine; Zamurovic, Natasa; Balavenkatraman, Kamal Kumar; Morawiec, Laurent; Kreutzer, Robert; Schelle, Juliane; Jucker, Mathias; Bertschi, Barbara; Theil, Diethilde; Heier, Annabelle; Bigot, Karine; Beltz, Karen; Machauer, Rainer; Brzak, Irena; Perrot, Ludovic; Neumann, Ulf.
Afiliação
  • Shimshek DR; Neuroscience, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Jacobson LH; Neuroscience, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Kolly C; Preclinical Safety, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Zamurovic N; Preclinical Safety, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Balavenkatraman KK; Preclinical Safety, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Morawiec L; Preclinical Safety, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Kreutzer R; Preclinical Safety, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Schelle J; Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen and German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
  • Jucker M; Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen and German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
  • Bertschi B; Preclinical Safety, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Theil D; Preclinical Safety, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Heier A; Preclinical Safety, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Bigot K; Preclinical Safety, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Beltz K; Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Machauer R; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Brzak I; Neuroscience, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Perrot L; Neuroscience, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  • Neumann U; Neuroscience, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
Sci Rep ; 6: 21917, 2016 Feb 25.
Article em En | MEDLINE | ID: mdl-26912421
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide / Antígeno gp100 de Melanoma / Cabelo Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide / Antígeno gp100 de Melanoma / Cabelo Idioma: En Ano de publicação: 2016 Tipo de documento: Article