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Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.
Wang, Yunpeng; Bos, Steffan D; Harbo, Hanne F; Thompson, Wesley K; Schork, Andrew J; Bettella, Francesco; Witoelar, Aree; Lie, Benedicte A; Li, Wen; McEvoy, Linda K; Djurovic, Srdjan; Desikan, Rahul S; Dale, Anders M; Andreassen, Ole A.
Afiliação
  • Wang Y; NORMENT, K.G. Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway/Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway/Multimodal Imaging Laboratory, University of California, San Diego, La Jolla,
  • Bos SD; Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway/Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Harbo HF; Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway/Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Thompson WK; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Schork AJ; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA/Cognitive Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA/Center for Human Development, University of California, San Diego, La Jolla, CA, USA.
  • Bettella F; NORMENT, K.G. Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway/Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Witoelar A; NORMENT, K.G. Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway/Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Lie BA; Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.
  • Li W; NORMENT, K.G. Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway/Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • McEvoy LK; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA/Department of Radiology, University of California-San Diego, La Jolla, CA, USA.
  • Djurovic S; NORMENT, K.G. Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway/Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway/Department of Medical Genetics, Oslo University Hospital and University of Osl
  • Desikan RS; Department of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, USA.
  • Dale AM; NORMENT, K.G. Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway/Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA/Multimodal Imaging Laboratory, University of California, San Diego, La Jolla,
  • Andreassen OA; NORMENT, K.G. Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway/Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway/Department of Psychiatry, University of California, San Diego, La Jolla, CA, U
Mult Scler ; 22(14): 1783-1793, 2016 12.
Article em En | MEDLINE | ID: mdl-26920376
ABSTRACT

BACKGROUND:

Epidemiological findings suggest a relationship between multiple sclerosis (MS) and cardiovascular disease (CVD) risk factors, although the nature of this relationship is not well understood.

OBJECTIVE:

We used genome-wide association study (GWAS) data to identify shared genetic factors (pleiotropy) between MS and CVD risk factors.

METHODS:

Using summary statistics from a large, recent GWAS (total n > 250,000 individuals), we investigated overlap in single nucleotide polymorphisms (SNPs) associated with MS and a number of CVD risk factors including triglycerides (TG), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, body mass index, waist-to-hip ratio, type 2 diabetes, systolic blood pressure, and C-reactive protein level. RESULTS AND

CONCLUSION:

Using conditional enrichment plots, we found 30-fold enrichment of MS SNPs for different levels of association with LDL and TG SNPs, with a corresponding reduction in conditional false discovery rate (FDR). We identified 133 pleiotropic loci outside the extended major histocompatibility complex with conditional FDR < 0.01, of which 65 are novel. These pleiotropic loci were located on 21 different chromosomes. Our findings point to overlapping pathobiology between clinically diagnosed MS and cardiovascular risk factors and identify novel common variants associated with increased MS risk.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Estudo de Associação Genômica Ampla / Esclerose Múltipla Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Estudo de Associação Genômica Ampla / Esclerose Múltipla Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article