Hepatitis E virus infection as a direct cause of neuralgic amyotrophy.
Muscle Nerve
; 54(2): 325-7, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-26939568
ABSTRACT
INTRODUCTION:
We describe a patient who developed neuralgic amyotrophy (NA) related to hepatitis E virus (HEV) infection.METHODS:
The patient underwent neurological and electrodiagnostic examinations, high-resolution analysis of serological changes, and HEV load profile, and was treated with intravenous immunoglobulin.RESULTS:
There was evidence of bilateral, asymmetric acute inflammatory cervical polyradiculopathy and possible brachial plexopathy. Positive serum anti-HEV IgM was followed by seroconversion to anti-HEV IgG positivity. A calculated anti-HEV antibody index was compatible with intrathecal synthesis, and HEV genotype 3 RNA was found in serum and cerebrospinal fluid (CSF). Liver function tests returned to normal within 6 weeks.CONCLUSIONS:
Bilateral involvement of cervical nerve roots and/or plexus, elevated liver function tests, and abnormal CSF are typical features of HEV-associated NA. The pathogenesis involves possible immune-mediated mechanisms. However, our findings support the hypothesis that HEV-related NA is associated with direct infection. Muscle Nerve 54 325-327, 2016.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neurite do Plexo Braquial
/
Vírus da Hepatite E
/
Hepatite E
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article