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Acoustic radiation force impulse sonography in assessing children with biliary atresia for liver transplantation.
Hanquinet, Sylviane; Courvoisier, Delphine S; Rougemont, Anne-Laure; Wildhaber, Barbara E; Merlini, Laura; McLin, Valérie A; Anooshiravani, Mehrak.
Afiliação
  • Hanquinet S; Department of Pediatric Radiology, Children's University Hospital of Geneva, 6 rue Willy Donzé, Ch 1211, Genève 14, Switzerland. sylviane.hanquinet-ginter@hcuge.ch.
  • Courvoisier DS; Division of Quality of Care, University Hospital of Geneva, Geneva, Switzerland.
  • Rougemont AL; Division of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.
  • Wildhaber BE; Department of Pediatric Surgery, Children's University Hospital of Geneva, Geneva, Switzerland.
  • Merlini L; Department of Pediatric Radiology, Children's University Hospital of Geneva, 6 rue Willy Donzé, Ch 1211, Genève 14, Switzerland.
  • McLin VA; Department of Pediatric Gastroenterology, Children's University Hospital of Geneva, Geneva, Switzerland.
  • Anooshiravani M; Department of Pediatric Radiology, Children's University Hospital of Geneva, 6 rue Willy Donzé, Ch 1211, Genève 14, Switzerland.
Pediatr Radiol ; 46(7): 1011-6, 2016 Jun.
Article em En | MEDLINE | ID: mdl-26939975
ABSTRACT

BACKGROUND:

Children with biliary atresia are prone to developing progressive hepatic fibrosis and biliary cirrhosis following the Kasai operation. The only treatment is liver transplantation.

OBJECTIVE:

To assess liver fibrosis by acoustic radiation force impulse elastography (ARFI) in children who had Kasai operation, with the goal of identifying an ARFI value cut-off for children requiring liver transplantation. MATERIALS AND

METHODS:

Of the 32 post-Kasai children included, 19 were transplanted or listed for transplantation (group A), while 13 were not on the list during their follow-up (group B). We recorded biopsies, blood samples and ARFI values over time, including at Kasai operation and at transplantation. We estimated an association between groups and continuous variables using generalized estimating equations, and we compared categorical variables using the Fisher exact test.

RESULTS:

Portal hypertension signs were similar in both groups, whereas ARFI values were higher in group A (mean±standard deviation=3.3±1.2 m/s) than in group B (2.0±0.7 m/s; P=.0003). Eighteen of 19 (94.7%) children in group A and 6/13 (46.2%) children in group B presented with two consecutive ARFI values ≥2 m/s (sensitivity=7%, specificity=53.8%; P=0.003).

CONCLUSION:

We found that children who were transplanted had two consecutive ARFI values ≥2 m/s during follow-up. ARFI for evaluation of post-Kasai liver fibrosis may assist the long-term assessment of biliary atresia and may even guide treatment decisions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atresia Biliar / Transplante de Fígado / Técnicas de Imagem por Elasticidade Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atresia Biliar / Transplante de Fígado / Técnicas de Imagem por Elasticidade Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article