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Multifunctional Nanotherapeutics with All-in-One Nanoentrapment of Drug/Gene/Inorganic Nanoparticle.
Jia, Hui-Zhen; Wang, Wei; Zheng, Di-Wei; Wang, Xuli; Yu, Wu-Yang; Li, Shi-Ying; Zhuo, Ren-Xi; Zhao, Yi-Fang; Feng, Jun; Zhang, Xian-Zheng.
Afiliação
  • Jia HZ; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
  • Wang W; School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University , Tianjin 300072, China.
  • Zheng DW; The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, and Department of Oral and Maxillofacial Surgery School & Hospital of Stomatology, Wuhan University , Wuhan 430079, China.
  • Wang X; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
  • Yu WY; Department of Phamaceutics and Pharmaceutical Chemistry, University of Utah , Salt Lake City, Utah 84108, United States.
  • Li SY; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
  • Zhuo RX; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
  • Zhao YF; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
  • Feng J; School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University , Tianjin 300072, China.
  • Zhang XZ; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
ACS Appl Mater Interfaces ; 8(11): 6784-9, 2016 Mar 23.
Article em En | MEDLINE | ID: mdl-26962876
ABSTRACT
It is challenging but imperative to merge together specific inorganic nanomaterials with macromolecular and small-molecule therapeutics into one nanoentity for all-in-one theranostic/remedy. We establish a versatile nanotechnology to nanoentrap magnetic nanoparticles, doxorubicin, and DNA, thus allowing the combination of magnetic targeting, magnetic resonance (MR) imaging, gene transport, and bioresponsive chemotherapy. We hope this nanotechnology can prompt the development of complex inorganic/organic nanosystems for various applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Sistemas de Liberação de Medicamentos / Técnicas de Transferência de Genes / Meios de Contraste / Nanopartículas / Campos Magnéticos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Sistemas de Liberação de Medicamentos / Técnicas de Transferência de Genes / Meios de Contraste / Nanopartículas / Campos Magnéticos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article