Histiocytosis with mixed cell populations.
J Cutan Pathol
; 43(5): 456-60, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26968131
ABSTRACT
Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. We describe an exceptional case of multiple cutaneous lesions in a 10-year-old boy, in which the coexistence of both LCH and JXG cell populations is found in every single lesion. The presence of Birbeck granules and CD207 (langerin) immunostaining in the LCH component would argue against the diagnosis of indeterminate cell histiocytosis (ICH). This unique case gives additional support to the hypothesis of a potentially common histogenesis for LCH and JXG.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Antígenos CD
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Histiocitose de Células de Langerhans
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Xantogranuloma Juvenil
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Lectinas Tipo C
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Lectinas de Ligação a Manose
Limite:
Child
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Humans
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Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article