Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system.

Biswas, Nilima; Maihofer, Adam X; Mir, Saiful Anam; Rao, Fangwen; Zhang, Kuixing; Khandrika, Srikrishna; Mahata, Manjula; Friese, Ryan S; Hightower, C Makena; Mahata, Sushil K; Baker, Dewleen G; Nievergelt, Caroline M; Vaingankar, Sucheta M; O'Connor, Daniel T

Biswas, Nilima; Maihofer, Adam X; Mir, Saiful Anam; Rao, Fangwen; Zhang, Kuixing; Khandrika, Srikrishna; Mahata, Manjula; Friese, Ryan S; Hightower, C Makena; Mahata, Sushil K; Baker, Dewleen G; Nievergelt, Caroline M; Vaingankar, Sucheta M; O'Connor, Daniel T.

Afiliação

Biswas N; Departments of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA. nbiswas33@gmail.com.
Maihofer AX; Veteran Affairs (VA) San Diego Health Care System and VA Center of Excellence for Stress and Mental Health, 3350 La Jolla Village Drive, San Diego, 92161, USA.
Mir SA; Departments of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
Rao F; Departments of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
Zhang K; Departments of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
Khandrika S; Departments of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
Mahata M; Departments of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
Friese RS; Departments of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
Hightower CM; Departments of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
Mahata SK; Departments of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
Baker DG; Department of Psychiatry, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
Nievergelt CM; Veteran Affairs (VA) San Diego Health Care System and VA Center of Excellence for Stress and Mental Health, 3350 La Jolla Village Drive, San Diego, 92161, USA.
Vaingankar SM; Department of Psychiatry, University of California at San Diego, 9500 Gilman Drive, La Jolla, 92093-0838, USA.
O'Connor DT; Veteran Affairs (VA) San Diego Health Care System and VA Center of Excellence for Stress and Mental Health, 3350 La Jolla Village Drive, San Diego, 92161, USA. cnievergelt@ucsd.edu.

BMC Med Genet ; 17: 21, 2016 Mar 11.

Article em En | MEDLINE | ID: mdl-26969407

Assuntos

Fator XIIa/genética; Calicreínas/genética; Polimorfismo de Nucleotídeo Único; Sistema Renina-Angiotensina/genética; Renina/sangue; Adolescente; Adulto; Idoso; Alelos; Angiotensina I/sangue; Angiotensinogênio/sangue; Animais; Pressão Sanguínea; Proteínas de Ciclo Celular; Linhagem Celular; Regulação da Expressão Gênica; Loci Gênicos; Estudo de Associação Genômica Ampla; Técnicas de Genotipagem; Humanos; Hipertensão/genética; Sistema Justaglomerular/citologia; Calicreínas/sangue; Masculino; Camundongos; Pessoa de Meia-Idade; Proteínas do Tecido Nervoso/genética; Proteínas do Tecido Nervoso/metabolismo; Pré-Calicreína/metabolismo; Renina/genética; Serina Endopeptidases/metabolismo; Transferases; Adulto Jovem

Palavras-chave

FXIIa (active protease encoded by gene F12 or Hageman factor); Hypertension; Kallikrein/KAL (active protease encoded for by gene KLKB1 or Fletcher factor); PTSD (posttraumatic stress disorder); rs1801020; rs3733402

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Renina-Angiotensina / Calicreínas / Fator XIIa / Renina / Polimorfismo de Nucleotídeo Único Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Animals / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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