Could the PI3K canonical pathway be a common link between chronic inflammatory conditions and oral carcinogenesis?
J Oral Pathol Med
; 45(7): 469-74, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-26991523
ABSTRACT
The association between chronic inflammatory disorders and oral carcinogenesis has been both a source of interest and contention. Based upon its central importance in oral carcinogenesis, the finding that the PI3k/Akt/mTOR pathway is activated in oral lichen planus, chronic graft-versus-host disease, and chronic oral candidiasis suggests that it may provide a link between benign and malignant oral conditions. Here, we discuss a possible mechanistic rationale that addresses the activation of this important signaling pathway and its downstream events, while correlating it with the carcinogenic potential of chronic oral disorders.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
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Fosfatidilinositol 3-Quinases
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Carcinogênese
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Inflamação
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article