Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer's disease-like pathologies in APP/PS1 transgenic mice.

Wang, Qing-Hua; Wang, Ye-Ran; Zhang, Tao; Jiao, Shu-Sheng; Liu, Yu-Hui; Zeng, Fan; Li, Jing; Yao, Xiu-Qing; Zhou, Hua-Dong; Zhou, Xin-Fu; Wang, Yan-Jiang

Wang, Qing-Hua; Wang, Ye-Ran; Zhang, Tao; Jiao, Shu-Sheng; Liu, Yu-Hui; Zeng, Fan; Li, Jing; Yao, Xiu-Qing; Zhou, Hua-Dong; Zhou, Xin-Fu; Wang, Yan-Jiang.

Afiliação

Wang QH; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Wang YR; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Zhang T; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Jiao SS; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Liu YH; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Zeng F; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Li J; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Yao XQ; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Zhou HD; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Zhou XF; Division of Health Sciences, School of Pharmacy and Medical Sciences and Sansom Institute, University of South Australia, Adelaide, South Australia, Australia.
Wang YJ; Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.

J Neurochem ; 138(1): 163-73, 2016 07.

Article em En | MEDLINE | ID: mdl-26991827

Assuntos

Doença de Alzheimer/patologia; Doença de Alzheimer/terapia; Transtornos Cognitivos/terapia; Receptor de Fator de Crescimento Neural/química; Receptor de Fator de Crescimento Neural/metabolismo; Doença de Alzheimer/genética; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Animais; Transtornos Cognitivos/genética; Dependovirus/genética; Modelos Animais de Doenças; Vetores Genéticos; Proteínas de Fluorescência Verde/genética; Proteínas de Fluorescência Verde/metabolismo; Humanos; Injeções Intramusculares; Aprendizagem em Labirinto/fisiologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Mutação/genética; Presenilina-1/genética; Receptor de Fator de Crescimento Neural/genética; Transdução Genética

Palavras-chave

Alzheimer's disease; amyloid-beta; ectodomain; gene therapy; intramuscular delivery; p75NTR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Cognitivos / Receptor de Fator de Crescimento Neural / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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