Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion.

Vellinga, T T; den Uil, S; Rinkes, I H B; Marvin, D; Ponsioen, B; Alvarez-Varela, A; Fatrai, S; Scheele, C; Zwijnenburg, D A; Snippert, H; Vermeulen, L; Medema, J P; Stockmann, H B; Koster, J; Fijneman, R J A; de Rooij, J; Kranenburg, O

Vellinga, T T; den Uil, S; Rinkes, I H B; Marvin, D; Ponsioen, B; Alvarez-Varela, A; Fatrai, S; Scheele, C; Zwijnenburg, D A; Snippert, H; Vermeulen, L; Medema, J P; Stockmann, H B; Koster, J; Fijneman, R J A; de Rooij, J; Kranenburg, O.

Afiliação

Vellinga TT; Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
den Uil S; Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
Rinkes IH; Department of Surgery, Spaarne Gasthuis, Haarlem, The Netherlands.
Marvin D; Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Ponsioen B; Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Alvarez-Varela A; Department Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Fatrai S; Department Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Scheele C; Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Zwijnenburg DA; Department Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Snippert H; Department of Oncogenomics, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
Vermeulen L; Department Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Medema JP; Center of Experimental and Molecular Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
Stockmann HB; Center of Experimental and Molecular Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
Koster J; Department of Surgery, Spaarne Gasthuis, Haarlem, The Netherlands.
Fijneman RJ; Center of Experimental and Molecular Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
de Rooij J; Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
Kranenburg O; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Oncogene ; 35(40): 5263-5271, 2016 10 06.

Article em En | MEDLINE | ID: mdl-26996663

Assuntos

Neoplasias do Colo/genética; Transição Epitelial-Mesenquimal/genética; Fator 4 Nuclear de Hepatócito/genética; Microambiente Tumoral/genética; Diferenciação Celular/genética; Linhagem Celular Tumoral; Movimento Celular/genética; Proliferação de Células/genética; Colágeno/genética; Colágeno/metabolismo; Neoplasias do Colo/patologia; Regulação Neoplásica da Expressão Gênica; Humanos; Células Estromais/metabolismo; Células Estromais/patologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Fator 4 Nuclear de Hepatócito / Transição Epitelial-Mesenquimal / Microambiente Tumoral Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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