Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress.

Scheid, Lisa-Mareike; Mosqueira, Matias; Hein, Selina; Kossack, Mandy; Juergensen, Lonny; Mueller, Marion; Meder, Benjamin; Fink, Rainer H A; Katus, Hugo A; Hassel, David

Scheid, Lisa-Mareike; Mosqueira, Matias; Hein, Selina; Kossack, Mandy; Juergensen, Lonny; Mueller, Marion; Meder, Benjamin; Fink, Rainer H A; Katus, Hugo A; Hassel, David.

Afiliação

Scheid LM; Medical Biophysics Unit, Institute of Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.
Mosqueira M; Medical Biophysics Unit, Institute of Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.
Hein S; Department of Medicine III, Cardiology, University Hospital of Heidelberg, 69120 Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Kossack M; Department of Medicine III, Cardiology, University Hospital of Heidelberg, 69120 Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Juergensen L; Department of Medicine III, Cardiology, University Hospital of Heidelberg, 69120 Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Mueller M; Department of Medicine III, Cardiology, University Hospital of Heidelberg, 69120 Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Meder B; Department of Medicine III, Cardiology, University Hospital of Heidelberg, 69120 Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Fink RH; Medical Biophysics Unit, Institute of Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.
Katus HA; Department of Medicine III, Cardiology, University Hospital of Heidelberg, 69120 Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Hassel D; Department of Medicine III, Cardiology, University Hospital of Heidelberg, 69120 Heidelberg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany david.hassel@med.uni-heidelberg.de.

Cardiovasc Res ; 111(1): 44-55, 2016 07 01.

Article em En | MEDLINE | ID: mdl-27013636

Assuntos

Cardiomiopatias/metabolismo; Insuficiência Cardíaca/metabolismo; Miocárdio/metabolismo; Cadeias Leves de Miosina/metabolismo; Estresse Fisiológico; Proteínas de Peixe-Zebra/metabolismo; Peixe-Zebra/metabolismo; Adaptação Fisiológica; Animais; Animais Geneticamente Modificados; Cardiomiopatias/genética; Cardiomiopatias/patologia; Cardiomiopatias/fisiopatologia; Modelos Animais de Doenças; Acoplamento Excitação-Contração; Predisposição Genética para Doença; Insuficiência Cardíaca/genética; Insuficiência Cardíaca/patologia; Insuficiência Cardíaca/fisiopatologia; Heterozigoto; Força Muscular; Mutação; Miocárdio/patologia; Cadeias Leves de Miosina/genética; Fenótipo; Fosforilação; Fatores de Tempo; Função Ventricular; Peixe-Zebra/genética; Proteínas de Peixe-Zebra/genética

Palavras-chave

Animal models of human disease; Functional genomics; Genetics of cardiovascular disease; Myocardial cardiomyopathy disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Peixe-Zebra / Cadeias Leves de Miosina / Proteínas de Peixe-Zebra / Insuficiência Cardíaca / Cardiomiopatias / Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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