Different cutaneous innate immunity profiles in acne patients with and without atrophic scars.
Eur J Dermatol
; 26(1): 68-74, 2016.
Article
em En
| MEDLINE
| ID: mdl-27018005
ABSTRACT
BACKGROUND:
Acne is a chronic inflammatory disease associated with scar development in many patients.OBJECTIVES:
To check whether early inflammatory events in the epidermis via keratinocytes influence the development of scars in acne patients.METHODS:
We investigated several immunological markers involved in epidermal innate immunity in both clinically normal skin and inflammatory early papules in acne patients prone to scars or not.RESULTS:
In normal skin of acne patients prone to scars vs not prone to scars, TLR-4, IL-2, IL-10, TIMP-2 and JUN were significantly overexpressed and the MMP-9 protein level was decreased. Similar results were obtained in early inflammatory papules (no more than three days), except for TLR-4.CONCLUSION:
These results suggest for the first time a link between the early events of inflammation with levels of activation of innate immunity in normal epidermis of acne patients and the development of scars. These markers could be a target for drugs in the field of scar prevention.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Cicatriz
/
Acne Vulgar
/
Imunidade Inata
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article