The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1&#945; Transcriptional Coactivator.

Tavares, Clint D J; Sharabi, Kfir; Dominy, John E; Lee, Yoonjin; Isasa, Marta; Orozco, Jose M; Jedrychowski, Mark P; Kamenecka, Theodore M; Griffin, Patrick R; Gygi, Steven P; Puigserver, Pere

The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.

Tavares, Clint D J; Sharabi, Kfir; Dominy, John E; Lee, Yoonjin; Isasa, Marta; Orozco, Jose M; Jedrychowski, Mark P; Kamenecka, Theodore M; Griffin, Patrick R; Gygi, Steven P; Puigserver, Pere.

Afiliação

Tavares CD; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Sharabi K; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Dominy JE; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Lee Y; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Isasa M; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Orozco JM; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Jedrychowski MP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Kamenecka TM; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458.
Griffin PR; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458.
Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.
Puigserver P; From the Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and pere_puigserver@dfci.harvard.edu.

J Biol Chem ; 291(20): 10635-45, 2016 May 13.

Article em En | MEDLINE | ID: mdl-27022023

Assuntos

Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos; Gluconeogênese/efeitos dos fármacos; Histona Acetiltransferases/biossíntese; Fígado/metabolismo; Metionina/farmacologia; Fatores de Transcrição/metabolismo; Fatores de Transcrição de p300-CBP/biossíntese; Acetilação/efeitos dos fármacos; Animais; Gluconeogênese/genética; Células Hep G2; Histona Acetiltransferases/genética; Humanos; Camundongos; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo; Fatores de Transcrição/genética; Fatores de Transcrição de p300-CBP/genética

Palavras-chave

acetylation; acetyltransferase; gluconeogenesis; glucose-6-phosphatase (G6pc); methionine; methionine transamination; methylthiopropionic acid (MTP); peroxisome proliferator-activated receptor Î³ coactivator 1-α (PGC-1α) (PPARGC1α); phosphoenolpyruvate carboxykinase (Pck1); transcription coactivator

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Regulação Enzimológica da Expressão Gênica / Histona Acetiltransferases / Fatores de Transcrição de p300-CBP / Gluconeogênese / Fígado / Metionina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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