Identification of HNF-4&#945; as a key transcription factor to promote ChREBP expression in response to glucose.

Meng, Jian; Feng, Ming; Dong, Weibing; Zhu, Yemin; Li, Yakui; Zhang, Ping; Wu, Lifang; Li, Minle; Lu, Ying; Chen, Hanbei; Liu, Xing; Lu, Yan; Sun, Haipeng; Tong, Xuemei

Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose.

Meng, Jian; Feng, Ming; Dong, Weibing; Zhu, Yemin; Li, Yakui; Zhang, Ping; Wu, Lifang; Li, Minle; Lu, Ying; Chen, Hanbei; Liu, Xing; Lu, Yan; Sun, Haipeng; Tong, Xuemei.

Afiliação

Meng J; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Feng M; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Dong W; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Zhu Y; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Li Y; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Zhang P; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Wu L; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Li M; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Lu Y; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Chen H; Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665, Kong Jiang Road, Shanghai, 200092, China.
Liu X; Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197, Rui-Jin 2nd Road, Shanghai, 200025, China.
Lu Y; Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197, Rui-Jin 2nd Road, Shanghai, 200025, China.
Sun H; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.
Tong X; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China.

Sci Rep ; 6: 23944, 2016 Mar 31.

Article em En | MEDLINE | ID: mdl-27029511

Assuntos

Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/genética; Glucose/farmacologia; Fator 4 Nuclear de Hepatócito/genética; Hepatócitos/efeitos dos fármacos; Fígado/efeitos dos fármacos; Ativação Transcricional/efeitos dos fármacos; Animais; Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/metabolismo; Genes Reporter; Glucose/metabolismo; Células HEK293; Células Hep G2; Fator 4 Nuclear de Hepatócito/metabolismo; Hepatócitos/citologia; Hepatócitos/metabolismo; Humanos; Fígado/citologia; Fígado/metabolismo; Luciferases/genética; Luciferases/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Motivos de Nucleotídeos; Cultura Primária de Células; Regiões Promotoras Genéticas; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Transdução de Sinais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Transcricional / Hepatócitos / Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos / Fator 4 Nuclear de Hepatócito / Glucose / Fígado Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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