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CD55 is a HIF-2α marker with anti-adhesive and pro-invading properties in neuroblastoma.
Cimmino, F; Avitabile, M; Pezone, L; Scalia, G; Montanaro, D; Andreozzi, M; Terracciano, L; Iolascon, A; Capasso, M.
Afiliação
  • Cimmino F; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli 'Federico II', Naples, Italy.
  • Avitabile M; CEINGE Biotecnologie Avanzate, Naples, Italy.
  • Pezone L; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli 'Federico II', Naples, Italy.
  • Scalia G; CEINGE Biotecnologie Avanzate, Naples, Italy.
  • Montanaro D; CEINGE Biotecnologie Avanzate, Naples, Italy.
  • Andreozzi M; Dipartimento di Medicina, Scuola di Medicina e Chirurgia, Università degli Studi di Verona, Verona, Italy.
  • Terracciano L; CEINGE Biotecnologie Avanzate, Naples, Italy.
  • Iolascon A; CEINGE Biotecnologie Avanzate, Naples, Italy.
  • Capasso M; Institute of Pathology, University of Basel, Basel, Switzerland.
Oncogenesis ; 5: e212, 2016 Apr 04.
Article em En | MEDLINE | ID: mdl-27043658
CD55 has been revealed to have an important role in tumor genesis, and presence of small populations of cells with strong CD55 expression would be sufficient to predict poor prognosis of several tumors. In our study we revealed that CD55 is a novel target of hypoxia-inducible factor HIF-2α in neuroblastoma (NB) cells. We show that HIF-2α expression is sufficient to sustain stem-like features of NB cells, whereas CD55 protein upon HIF-2α expression contributes to growth of colonies and to invasion of cells, but not to stemness features. Interestingly, in NB tissues, CD55 expression is limited to quite a small population of cells that are HIF-2α positive, and the gene expression of CD55 in the NB data set reveals that the presence of CD55(high) affects prognosis of NB patients. The functional characterization of CD55-positive populations within heterogeneous NB monoclonal cell lines shows that CD55 has pro-invading and anti-adhesive properties that might provide the basis for the ability of solid tumors to survive as microscopic residual disease. The easy accessibility to CD55 membrane antigen will offer the possibility of a novel antibody approach in the treatment of recurrent tumors and will provide a ready target for antibody-based visualization in NB diagnosis and prognosis.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article