Treatment with anti-RANKL antibody reduces infarct size and attenuates dysfunction impacting on neutrophil-mediated injury.

Carbone, Federico; Crowe, Lindsey A; Roth, Aline; Burger, Fabienne; Lenglet, Sébastien; Braunersreuther, Vincent; Brandt, Karim J; Quercioli, Alessandra; Mach, François; Vallée, Jean-Paul; Montecucco, Fabrizio

Carbone, Federico; Crowe, Lindsey A; Roth, Aline; Burger, Fabienne; Lenglet, Sébastien; Braunersreuther, Vincent; Brandt, Karim J; Quercioli, Alessandra; Mach, François; Vallée, Jean-Paul; Montecucco, Fabrizio.

Afiliação

Carbone F; Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, University of Geneva, 1211 Geneva, Switzerland.
Crowe LA; Division of Radiology, Geneva University Hospital and Faculty of Medicine, 1205 Geneva, Switzerland.
Roth A; Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, University of Geneva, 1211 Geneva, Switzerland.
Burger F; Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, University of Geneva, 1211 Geneva, Switzerland.
Lenglet S; Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, University of Geneva, 1211 Geneva, Switzerland.
Braunersreuther V; Division of Pathology, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Brandt KJ; Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, University of Geneva, 1211 Geneva, Switzerland.
Quercioli A; Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, University of Geneva, 1211 Geneva, Switzerland.
Mach F; Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, University of Geneva, 1211 Geneva, Switzerland.
Vallée JP; Division of Radiology, Geneva University Hospital and Faculty of Medicine, 1205 Geneva, Switzerland.
Montecucco F; First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine and IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 6 viale Benedetto XV, 16132 Genoa, Italy. Electronic address: Fabrizio.montecucco@unige

J Mol Cell Cardiol ; 94: 82-94, 2016 05.

Article em En | MEDLINE | ID: mdl-27056420

Assuntos

Anticorpos Monoclonais/farmacologia; Infarto do Miocárdio/patologia; Infarto do Miocárdio/fisiopatologia; Neutrófilos/efeitos dos fármacos; Ligante RANK/antagonistas & inibidores; Disfunção Ventricular/tratamento farmacológico; Animais; Biomarcadores; Degranulação Celular; Citocinas/sangue; Citocinas/metabolismo; Modelos Animais de Doenças; Mediadores da Inflamação/sangue; Mediadores da Inflamação/metabolismo; Subpopulações de Linfócitos/patologia; Macrófagos/patologia; Imageamento por Ressonância Magnética; Masculino; Camundongos; Infarto do Miocárdio/tratamento farmacológico; Infarto do Miocárdio/etiologia; Traumatismo por Reperfusão Miocárdica/tratamento farmacológico; Traumatismo por Reperfusão Miocárdica/metabolismo; Traumatismo por Reperfusão Miocárdica/patologia; Traumatismo por Reperfusão Miocárdica/fisiopatologia; Infiltração de Neutrófilos; Neutrófilos/imunologia; Neutrófilos/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Ligante RANK/metabolismo; Troponina I/sangue; Troponina I/metabolismo

Palavras-chave

Inflammation; Myocardial infarction; Neutrophils

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Ventricular / Ligante RANK / Anticorpos Monoclonais / Infarto do Miocárdio / Neutrófilos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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