Synthesis of a doxycycline-[(13) CD3 ] standard.
J Labelled Comp Radiopharm
; 59(7): 291-3, 2016 06 15.
Article
em En
| MEDLINE
| ID: mdl-27061598
ABSTRACT
A stable isotope labelled mass spectrometry internal standard of the antibiotic doxycycline was prepared to assist in pharmacokinetic analyses. Our approach was to first N-demethylate doxycycline using a non-classical Polonovski reaction and then re-methylate using methyl-[(13) CD3 ] iodide, which gave doxycycline-[(13) CD3 ] with an isotopic purity of 99%.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radioquímica
/
Doxiciclina
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article