Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.

Teachey, David T; Lacey, Simon F; Shaw, Pamela A; Melenhorst, J Joseph; Maude, Shannon L; Frey, Noelle; Pequignot, Edward; Gonzalez, Vanessa E; Chen, Fang; Finklestein, Jeffrey; Barrett, David M; Weiss, Scott L; Fitzgerald, Julie C; Berg, Robert A; Aplenc, Richard; Callahan, Colleen; Rheingold, Susan R; Zheng, Zhaohui; Rose-John, Stefan; White, Jason C; Nazimuddin, Farzana; Wertheim, Gerald; Levine, Bruce L; June, Carl H; Porter, David L; Grupp, Stephan A

Teachey, David T; Lacey, Simon F; Shaw, Pamela A; Melenhorst, J Joseph; Maude, Shannon L; Frey, Noelle; Pequignot, Edward; Gonzalez, Vanessa E; Chen, Fang; Finklestein, Jeffrey; Barrett, David M; Weiss, Scott L; Fitzgerald, Julie C; Berg, Robert A; Aplenc, Richard; Callahan, Colleen; Rheingold, Susan R; Zheng, Zhaohui; Rose-John, Stefan; White, Jason C; Nazimuddin, Farzana; Wertheim, Gerald; Levine, Bruce L; June, Carl H; Porter, David L; Grupp, Stephan A.

Afiliação

Teachey DT; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphi
Lacey SF; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, The University
Shaw PA; Department of Biostatistics and Epidemiology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Melenhorst JJ; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, The University
Maude SL; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphi
Frey N; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Division of Hematology-Oncology, The University of Pennsylvania Perelman Sch
Pequignot E; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, The University
Gonzalez VE; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Chen F; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, The University
Finklestein J; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, The University
Barrett DM; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphi
Weiss SL; Department of Anesthesia and Critical Care Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Fitzgerald JC; Department of Anesthesia and Critical Care Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Berg RA; Department of Anesthesia and Critical Care Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Aplenc R; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphi
Callahan C; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Rheingold SR; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphi
Zheng Z; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, The University
Rose-John S; Institute of Biochemistry, CAU Kiel, Germany.
White JC; Fort Belvoir Community Hospital, Fort Belvoir, Virginia.
Nazimuddin F; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, The University
Wertheim G; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Levine BL; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, The University
June CH; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, The University
Porter DL; Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Division of Hematology-Oncology, The University of Pennsylvania Perelman Sch
Grupp SA; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphi

Cancer Discov ; 6(6): 664-79, 2016 06.

Article em En | MEDLINE | ID: mdl-27076371

Assuntos

Biomarcadores; Terapia Baseada em Transplante de Células e Tecidos/efeitos adversos; Citocinas/metabolismo; Imunoterapia/efeitos adversos; Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações; Síndrome de Lise Tumoral/etiologia; Síndrome de Lise Tumoral/metabolismo; Adolescente; Adulto; Idoso; Anticorpos Monoclonais Humanizados/uso terapêutico; Antígenos CD19/imunologia; Antígenos CD19/metabolismo; Terapia Baseada em Transplante de Células e Tecidos/métodos; Criança; Pré-Escolar; Feminino; Humanos; Imunoterapia/métodos; Masculino; Pessoa de Meia-Idade; Fenótipo; Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia; Prognóstico; Curva ROC; Receptores de Antígenos de Linfócitos T/genética; Receptores de Antígenos de Linfócitos T/imunologia; Receptores de Antígenos de Linfócitos T/metabolismo; Índice de Gravidade de Doença; Resultado do Tratamento; Síndrome de Lise Tumoral/diagnóstico; Síndrome de Lise Tumoral/tratamento farmacológico; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Síndrome de Lise Tumoral / Citocinas / Leucemia-Linfoma Linfoblástico de Células Precursoras / Terapia Baseada em Transplante de Células e Tecidos / Imunoterapia Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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