Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin.

Foley, Jonathan H; Walton, Bethany L; Aleman, Maria M; O'Byrne, Alice M; Lei, Victor; Harrasser, Micaela; Foley, Kimberley A; Wolberg, Alisa S; Conway, Edward M

Foley, Jonathan H; Walton, Bethany L; Aleman, Maria M; O'Byrne, Alice M; Lei, Victor; Harrasser, Micaela; Foley, Kimberley A; Wolberg, Alisa S; Conway, Edward M.

Afiliação

Foley JH; Centre for Blood Research, Department of Medicine, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, LSC4306, Vancouver V6T 1Z3, Canada; Department of Haematology, UCL Cancer Institute, University College London, London, United Kingdom; Katharine Dormandy Haemophili
Walton BL; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 819 Brinkhous-Bullitt Building, CB# 7525, Chapel Hill, NC 27599-7525, USA.
Aleman MM; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 819 Brinkhous-Bullitt Building, CB# 7525, Chapel Hill, NC 27599-7525, USA.
O'Byrne AM; Centre for Blood Research, Department of Medicine, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, LSC4306, Vancouver V6T 1Z3, Canada.
Lei V; Centre for Blood Research, Department of Medicine, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, LSC4306, Vancouver V6T 1Z3, Canada.
Harrasser M; Department of Haematology, UCL Cancer Institute, University College London, London, United Kingdom.
Foley KA; Cancer Care and Epidemiology, Queen's Cancer Research Institute, Queen's University, Kingston, Canada.
Wolberg AS; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 819 Brinkhous-Bullitt Building, CB# 7525, Chapel Hill, NC 27599-7525, USA.
Conway EM; Centre for Blood Research, Department of Medicine, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, LSC4306, Vancouver V6T 1Z3, Canada.

EBioMedicine ; 5: 175-82, 2016 Mar.

Article em En | MEDLINE | ID: mdl-27077125

Assuntos

Artérias/imunologia; Complemento C5a/imunologia; Fibrinolisina/imunologia; Trombose Venosa/imunologia; Animais; Antitrombina III/efeitos dos fármacos; Antitrombina III/imunologia; Artérias/efeitos dos fármacos; Artérias/patologia; Ativação do Complemento/efeitos dos fármacos; Ativação do Complemento/imunologia; Complemento C3a/biossíntese; Complemento C3a/imunologia; Complemento C5a/biossíntese; Complexo de Ataque à Membrana do Sistema Complemento/efeitos dos fármacos; Complexo de Ataque à Membrana do Sistema Complemento/imunologia; Fator Xa/imunologia; Fator Xa/metabolismo; Fibrinolisina/metabolismo; Humanos; Camundongos; Peptídeo Hidrolases/efeitos dos fármacos; Peptídeo Hidrolases/imunologia; Ativadores de Plasminogênio/administração & dosagem; Trombina/imunologia; Trombina/metabolismo; Trombose Venosa/tratamento farmacológico; Trombose Venosa/patologia

Palavras-chave

Complement; FDP, fibrin degradation product; FeCl3, ferric chloride; Fibrinolysis; IL-8, interleukin-8; IVC, inferior vena cava; Leukocytes; MAC, membrane attack complex; MCP1-1, monocyte chemoattracant protein-1; NETs, neutrophil extracellular traps; PAR1, protease activated receptor 1; PPACK, Phe-Pro-Arg-chloromethylketone; R751, arginine 751; TAT, thrombin antithrombin; Thrombin; Thrombosis; VFKck, Val-Phe-Lys-chloromethylketone; VWF, von Willebrand factor; tPA, tissue-type plasminogen activator

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artérias / Complemento C5a / Fibrinolisina / Trombose Venosa Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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