Whole-Body Distribution and Radiation Dosimetry of 11C-Elacridar and 11C-Tariquidar in Humans.

Bauer, Martin; Blaickner, Matthias; Philippe, Cécile; Wadsak, Wolfgang; Hacker, Marcus; Zeitlinger, Markus; Langer, Oliver

Bauer, Martin; Blaickner, Matthias; Philippe, Cécile; Wadsak, Wolfgang; Hacker, Marcus; Zeitlinger, Markus; Langer, Oliver.

Afiliação

Bauer M; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria martin.m.bauer@meduniwien.ac.at.
Blaickner M; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria; and.
Philippe C; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Wadsak W; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Hacker M; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Zeitlinger M; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Langer O; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria; and Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vi

J Nucl Med ; 57(8): 1265-8, 2016 Aug.

Article em En | MEDLINE | ID: mdl-27081167

Assuntos

Acridinas/análise; Acridinas/farmacocinética; Tomografia por Emissão de Pósitrons/métodos; Quinolinas/análise; Quinolinas/farmacocinética; Tetra-Hidroisoquinolinas/análise; Tetra-Hidroisoquinolinas/farmacocinética; Contagem Corporal Total/métodos; Adulto; Radioisótopos de Carbono; Humanos; Taxa de Depuração Metabólica; Especificidade de Órgãos; Doses de Radiação; Compostos Radiofarmacêuticos/análise; Compostos Radiofarmacêuticos/farmacocinética; Distribuição Tecidual

Palavras-chave

11C-elacridar; 11C-tariquidar; P-glycoprotein; breast cancer resistance protein; radiation dosimetry

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Acridinas / Contagem Corporal Total / Tetra-Hidroisoquinolinas / Tomografia por Emissão de Pósitrons Limite: Adult / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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