Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Babaev, Vladimir R; Yeung, Michele; Erbay, Ebru; Ding, Lei; Zhang, Youmin; May, James M; Fazio, Sergio; Hotamisligil, Gökhan S; Linton, MacRae F

Babaev, Vladimir R; Yeung, Michele; Erbay, Ebru; Ding, Lei; Zhang, Youmin; May, James M; Fazio, Sergio; Hotamisligil, Gökhan S; Linton, MacRae F.

Afiliação

Babaev VR; From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science Uni
Yeung M; From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science Uni
Erbay E; From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science Uni
Ding L; From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science Uni
Zhang Y; From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science Uni
May JM; From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science Uni
Fazio S; From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science Uni
Hotamisligil GS; From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science Uni
Linton MF; From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science Uni

Arterioscler Thromb Vasc Biol ; 36(6): 1122-31, 2016 06.

Article em En | MEDLINE | ID: mdl-27102962

Assuntos

Aorta/enzimologia; Doenças da Aorta/enzimologia; Apoptose; Aterosclerose/enzimologia; Células da Medula Óssea/enzimologia; Macrófagos/enzimologia; Proteína Quinase 8 Ativada por Mitógeno/deficiência; Receptores de LDL/deficiência; Animais; Aorta/efeitos dos fármacos; Aorta/patologia; Doenças da Aorta/genética; Doenças da Aorta/patologia; Apoptose/efeitos dos fármacos; Aterosclerose/genética; Aterosclerose/patologia; Células da Medula Óssea/efeitos dos fármacos; Células da Medula Óssea/patologia; Transplante de Medula Óssea; Sobrevivência Celular; Células Cultivadas; Dieta Hiperlipídica; Modelos Animais de Doenças; Estresse do Retículo Endoplasmático; Predisposição Genética para Doença; Hipercolesterolemia/enzimologia; Hipercolesterolemia/genética; Macrófagos/efeitos dos fármacos; Macrófagos/patologia; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteína Quinase 8 Ativada por Mitógeno/antagonistas & inibidores; Proteína Quinase 8 Ativada por Mitógeno/genética; Proteína Quinase 9 Ativada por Mitógeno/antagonistas & inibidores; Proteína Quinase 9 Ativada por Mitógeno/deficiência; Proteína Quinase 9 Ativada por Mitógeno/genética; PTEN Fosfo-Hidrolase/antagonistas & inibidores; PTEN Fosfo-Hidrolase/metabolismo; Fenótipo; Placa Aterosclerótica; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Receptores de LDL/genética; Transdução de Sinais; Proteína de Morte Celular Associada a bcl/metabolismo

Palavras-chave

MAP kinase signaling system; apoptosis; atherosclerosis; endoplasmic reticulum stress; macrophages

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta / Doenças da Aorta / Células da Medula Óssea / Receptores de LDL / Apoptose / Proteína Quinase 8 Ativada por Mitógeno / Aterosclerose / Macrófagos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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