Dexamethasone Attenuates LPS-induced Acute Lung Injury through Inhibition of NF-&#954;B, COX-2, and Pro-inflammatory Mediators.

Al-Harbi, Naif O; Imam, Faisal; Al-Harbi, Mohammed M; Ansari, Mushtaq Ahmad; Zoheir, Khairy M A; Korashy, Hesham M; Sayed-Ahmed, Mohamed M; Attia, Sabry M; Shabanah, Othman A; Ahmad, Sheikh Fayaz

Dexamethasone Attenuates LPS-induced Acute Lung Injury through Inhibition of NF-κB, COX-2, and Pro-inflammatory Mediators.

Al-Harbi, Naif O; Imam, Faisal; Al-Harbi, Mohammed M; Ansari, Mushtaq Ahmad; Zoheir, Khairy M A; Korashy, Hesham M; Sayed-Ahmed, Mohamed M; Attia, Sabry M; Shabanah, Othman A; Ahmad, Sheikh Fayaz.

Afiliação

Al-Harbi NO; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.
Imam F; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.
Al-Harbi MM; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.
Ansari MA; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.
Zoheir KM; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.
Korashy HM; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.
Sayed-Ahmed MM; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.
Attia SM; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.
Shabanah OA; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.
Ahmad SF; a Department of Pharmacology and Toxicology , College of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia.

Immunol Invest ; 45(4): 349-69, 2016 May.

Article em En | MEDLINE | ID: mdl-27104958

Assuntos

Lesão Pulmonar Aguda/tratamento farmacológico; Dexametasona/uso terapêutico; Interleucina-10/metabolismo; Pulmão/efeitos dos fármacos; Neutrófilos/efeitos dos fármacos; Animais; Células Cultivadas; Ciclo-Oxigenase 2/genética; Ciclo-Oxigenase 2/metabolismo; Humanos; Mediadores da Inflamação/metabolismo; Interleucina-10/genética; Interleucina-6/genética; Interleucina-6/metabolismo; Lipopolissacarídeos/imunologia; Pulmão/patologia; Masculino; Camundongos; Camundongos Endogâmicos BALB C; NF-kappa B/genética; NF-kappa B/metabolismo; Neutrófilos/imunologia; Transdução de Sinais/efeitos dos fármacos; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Cytokines; T cell receptors; dexamethasone; inflammatory mediators; lipopolysaccharides; nuclear factor-kappa B

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dexametasona / Interleucina-10 / Lesão Pulmonar Aguda / Pulmão / Neutrófilos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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