Endothelial-to-mesenchymal transition in lipopolysaccharide-induced acute lung injury drives a progenitor cell-like phenotype.

Suzuki, Toshio; Tada, Yuji; Nishimura, Rintaro; Kawasaki, Takeshi; Sekine, Ayumi; Urushibara, Takashi; Kato, Fumiaki; Kinoshita, Taku; Ikari, Jun; West, James; Tatsumi, Koichiro

Suzuki, Toshio; Tada, Yuji; Nishimura, Rintaro; Kawasaki, Takeshi; Sekine, Ayumi; Urushibara, Takashi; Kato, Fumiaki; Kinoshita, Taku; Ikari, Jun; West, James; Tatsumi, Koichiro.

Afiliação

Suzuki T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and toshiosuzuki@chiba-u.jp.
Tada Y; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and.
Nishimura R; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and.
Kawasaki T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and.
Sekine A; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and.
Urushibara T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and.
Kato F; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and.
Kinoshita T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and.
Ikari J; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and.
West J; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Tatsumi K; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan; and.

Am J Physiol Lung Cell Mol Physiol ; 310(11): L1185-98, 2016 06 01.

Article em En | MEDLINE | ID: mdl-27106288

Assuntos

Lesão Pulmonar Aguda/imunologia; Células Progenitoras Endoteliais/fisiologia; Lipopolissacarídeos/farmacologia; Lesão Pulmonar Aguda/patologia; Animais; Apoptose; Proliferação de Células; Transdiferenciação Celular; Células Cultivadas; Células Progenitoras Endoteliais/imunologia; Endotélio Vascular/imunologia; Endotélio Vascular/patologia; Feminino; Expressão Gênica; Camundongos Endogâmicos C57BL; NADPH Oxidases/metabolismo; Fenótipo; Espécies Reativas de Oxigênio/metabolismo; Fator de Crescimento Transformador beta1/biossíntese; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta2/biossíntese; Fator de Crescimento Transformador beta2/genética

Palavras-chave

acute lung injury; cell transformation; endothelial-to-mesenchymal transition; progenitor cells; reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Lesão Pulmonar Aguda / Células Progenitoras Endoteliais Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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