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The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
Haile, Pamela A; Votta, Bartholomew J; Marquis, Robert W; Bury, Michael J; Mehlmann, John F; Singhaus, Robert; Charnley, Adam K; Lakdawala, Ami S; Convery, Máire A; Lipshutz, David B; Desai, Biva M; Swift, Barbara; Capriotti, Carol A; Berger, Scott B; Mahajan, Mukesh K; Reilly, Michael A; Rivera, Elizabeth J; Sun, Helen H; Nagilla, Rakesh; Beal, Allison M; Finger, Joshua N; Cook, Michael N; King, Bryan W; Ouellette, Michael T; Totoritis, Rachel D; Pierdomenico, Maria; Negroni, Anna; Stronati, Laura; Cucchiara, Salvatore; Ziólkowski, Bartlomiej; Vossenkämper, Anna; MacDonald, Thomas T; Gough, Peter J; Bertin, John; Casillas, Linda N.
Afiliação
  • Convery MA; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre , Stevenage, SG1 2NY, UK.
  • Pierdomenico M; Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA) , 00196 Rome, Italy.
  • Negroni A; Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA) , 00196 Rome, Italy.
  • Stronati L; Department of Cellular Biotechnology and Hematology, Sapienza University Hospital Umberto I , 00161 Rome, Italy.
  • Cucchiara S; Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University Hospital Umberto I , 00161 Rome, Italy.
  • Ziólkowski B; Endoscopy Unit, Barts Health, Royal London Hospital , E1 1BB London, U.K.
  • Vossenkämper A; Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K.
  • MacDonald TT; Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K.
J Med Chem ; 59(10): 4867-80, 2016 05 26.
Article em En | MEDLINE | ID: mdl-27109867
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonas / Inibidores de Proteínas Quinases / Proteína Serina-Treonina Quinase 2 de Interação com Receptor / Aminoquinolinas Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonas / Inibidores de Proteínas Quinases / Proteína Serina-Treonina Quinase 2 de Interação com Receptor / Aminoquinolinas Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article