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Programmed death ligand-1 expression is associated with poor disease free survival in salivary gland carcinomas.
Mukaigawa, Takashi; Hayashi, Ryuichi; Hashimoto, Kazuki; Ugumori, Toru; Hato, Naohito; Fujii, Satoshi.
Afiliação
  • Mukaigawa T; Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
  • Hayashi R; Department of Otolaryngology, Head and Neck Surgery, Ehime University School of Medicine, Toon, Ehime, Japan.
  • Hashimoto K; Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
  • Ugumori T; Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
  • Hato N; Department of Otolaryngology, Head and Neck Surgery, Ehime University School of Medicine, Toon, Ehime, Japan.
  • Fujii S; Department of Otolaryngology, Head and Neck Surgery, Ehime University School of Medicine, Toon, Ehime, Japan.
J Surg Oncol ; 114(1): 36-43, 2016 Jul.
Article em En | MEDLINE | ID: mdl-27111278
BACKGROUND AND OBJECTIVES: The immune checkpoint ligand programmed death ligand-1 (PD-L1) is expressed in various carcinomas and allows carcinoma cells to elude the immune system. PD-L1 expression is associated with the response to anti-programmed death 1 (PD-1)/PD-L1 drugs. This study aimed to clarify the relationship between PD-L1 expression and clinicopathological factors of salivary gland carcinomas (SGCs) and identify its clinical significance. METHODS: PD-L1 expression was examined by immunohistochemical analysis using a tissue microarray comprised of 219 surgically resected SGC specimens. Detailed clinicopathological factors, including patient outcome, were available for all cases. RESULTS: A case showing complete membranous expression of PD-L1 in more than 1% of whole carcinoma cells was considered positive by ROC analysis. A total of 50 (22.8%) patients showed PD-L1 expression in SGC cells. Positive PD-L1 expression was significantly associated with poor disease free survival (P < 0.001) and overall survival (P < 0.001). Multivariate analysis revealed that positive PD-L1 expression was one of the independent predictors for poor disease free survival (hazard ratio = 2.287, 95% confidence interval = 1.24-4.15; P = 0.008). CONCLUSIONS: Positive PD-L1 expression was significantly associated with poor disease free survival of SGCs, suggesting that antibody therapies targeting PD-1/PD-L1 may have potential application in SGCs. J. Surg. Oncol. 2016;114:36-43. © 2016 Wiley Periodicals, Inc.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma / Biomarcadores Tumorais / Antígeno B7-H1 Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma / Biomarcadores Tumorais / Antígeno B7-H1 Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article