Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults.
Int J Geriatr Psychiatry
; 32(4): 414-420, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-27113813
ABSTRACT
OBJECTIVE:
To investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults.METHODS:
We performed a nationwide matched (age, sex, and case event day) case-control study between 1 January and 31 December 2011 based on several Swedish registers (n = 1,288,875 persons aged ≥65 years). We used multivariate conditional logistic regression adjusted for education, number of inpatient days, Charlson co-morbidity index, dementia and number of other drugs.RESULTS:
Antidepressants were the psychotropic most strongly related to fall injuries (ORadjusted 1.42; 95% CI 1.38-1.45) and antipsychotics to hospitalizations (ORadjusted 1.22; 95% CI 1.19-1.24) and death (ORadjusted 2.10; 95% CI 2.02-2.17). Number of psychotropics was associated with increased the risk of fall injuries, (4 psychotropics vs 0 ORadjusted 1.53; 95% CI 1.39-1.68), hospitalization (4 psychotropics vs 0 ORadjusted 1.27; 95% CI 1.22-1.33) and death (4 psychotropics vs 0 ORadjusted 2.50; 95% CI 2.33-2.69) in a dose-response manner. Among persons with dementia (n = 58,984), a dose-response relationship was found between number of psychotropics and mortality risk (4 psychotropics vs 0 ORadjusted 1.99; 95% CI 1.76-2.25).CONCLUSIONS:
Our findings support a cautious prescribing of multiple psychotropic drugs to older patients. © 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psicotrópicos
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Acidentes por Quedas
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Mortalidade
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Hospitalização
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Transtornos Mentais
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Aged80
/
Female
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Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article