Isolated limb perfusion with biochemotherapy and oncolytic virotherapy combines with radiotherapy and surgery to overcome treatment resistance in an animal model of extremity soft tissue sarcoma.

Wilkinson, Michelle J; Smith, Henry G; Pencavel, Timothy D; Mansfield, David C; Kyula-Currie, Joan; Khan, Aadil A; McEntee, Gráinne; Roulstone, Victoria; Hayes, Andrew J; Harrington, Kevin J

Wilkinson, Michelle J; Smith, Henry G; Pencavel, Timothy D; Mansfield, David C; Kyula-Currie, Joan; Khan, Aadil A; McEntee, Gráinne; Roulstone, Victoria; Hayes, Andrew J; Harrington, Kevin J.

Afiliação

Wilkinson MJ; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Smith HG; Sarcoma/Melanoma Unit, Department Of Academic Surgery, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.
Pencavel TD; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Mansfield DC; Sarcoma/Melanoma Unit, Department Of Academic Surgery, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.
Kyula-Currie J; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Khan AA; Sarcoma/Melanoma Unit, Department Of Academic Surgery, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.
McEntee G; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Roulstone V; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Hayes AJ; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Harrington KJ; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.

Int J Cancer ; 139(6): 1414-22, 2016 09 15.

Article em En | MEDLINE | ID: mdl-27116656

Assuntos

Antineoplásicos/administração & dosagem; Quimioterapia do Câncer por Perfusão Regional; Terapia Combinada; Terapia Viral Oncolítica; Radioterapia; Sarcoma/patologia; Animais; Apoptose/efeitos dos fármacos; Caspase 3/metabolismo; Linhagem Celular Tumoral; Modelos Animais de Doenças; Extremidades; Vetores Genéticos/genética; Humanos; Masculino; Melfalan/administração & dosagem; Terapia Viral Oncolítica/métodos; Vírus Oncolíticos/genética; Terapia com Prótons; Radioterapia/métodos; Ratos; Recidiva; Sarcoma/genética; Sarcoma/mortalidade; Sarcoma/terapia; Transdução Genética; Carga Tumoral/efeitos dos fármacos; Carga Tumoral/efeitos da radiação

Palavras-chave

isolated limb perfusion; oncolytic virotherapy; soft tissue sarcoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioterapia / Sarcoma / Quimioterapia do Câncer por Perfusão Regional / Terapia Combinada / Terapia Viral Oncolítica / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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