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5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
Parmar, Rubina; Willoughby, Jennifer L S; Liu, Jingxuan; Foster, Donald J; Brigham, Benjamin; Theile, Christopher S; Charisse, Klaus; Akinc, Akin; Guidry, Erin; Pei, Yi; Strapps, Walter; Cancilla, Mark; Stanton, Matthew G; Rajeev, Kallanthottathil G; Sepp-Lorenzino, Laura; Manoharan, Muthiah; Meyers, Rachel; Maier, Martin A; Jadhav, Vasant.
Afiliação
  • Parmar R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Willoughby JL; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Liu J; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Foster DJ; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Brigham B; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Theile CS; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Charisse K; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Akinc A; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Guidry E; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.
  • Pei Y; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.
  • Strapps W; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.
  • Cancilla M; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.
  • Stanton MG; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.
  • Rajeev KG; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Sepp-Lorenzino L; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Meyers R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Maier MA; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Jadhav V; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA. vjadhav@alnylam.com.
Chembiochem ; 17(11): 985-9, 2016 Jun 02.
Article em En | MEDLINE | ID: mdl-27121751
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilgalactosamina / Compostos de Vinila / RNA Interferente Pequeno / Interferência de RNA / Organofosfonatos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilgalactosamina / Compostos de Vinila / RNA Interferente Pequeno / Interferência de RNA / Organofosfonatos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article