Clinical Application of Endothelial Progenitor Cell: Are We Ready?
Acta Cardiol Sin
; 29(6): 479-87, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-27122748
ABSTRACT
UNLABELLED The discovery of circulating endothelial progenitor cells (EPCs) opened up a new era of EPC-based therapies for cardiovascular diseases. While researchers are enthusiastic about applying EPCs to clinical therapy, progress has been substantially limited due to the lack of a thorough characterization and understanding of early and late outgrowth EPCs (also called endothelial colony-forming cell, ECFCs) biology. As a means of facilitating the understanding of how late EPCs can most effectively be applied to clinical therapeutics, this article reviews the recent progress covering 5 important issues (1) The best passages of ex vivo-cultivated EPCs for cell therapy; (2) inflammatory activation of late EPCs a real world consideration; (3) late EPC is not an endothelial cell an issue of cell contamination; (4) ways to improve EPC function and differentiation; and (5) how to separate and delete smooth muscle progenitor cells (SPCs). KEY WORDS Cardiovascular disease; Cell therapy; Endothelial progenitor cell; Smooth muscle progenitor cell.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article