CORRELATIONS BETWEEN ARTERIAL HYPERTENSION INDUCED BY ANGIOTENSIN II AND SYSTEMIC INFLAMMATION IN RAT.
Rev Med Chir Soc Med Nat Iasi
; 120(1): 77-82, 2016.
Article
em En
| MEDLINE
| ID: mdl-27125076
ABSTRACT
UNLABELLED Angiotensin II has articularly shown to play a key role in the regulation of inflammatory processes in hypertension. AIM:
The present study aims to correlate the angiotensin II-induced hypertension 4th systemic inflammation. MATERIAL ANDMETHODS:
We conducted an experimental study on Wistar male rats who received Ang II via subcutaneous miniosmotic pumps for 2 weeks. Rats were exposed to a 12h light /12h dark cycle. Sham rats were used as control. Systolic load pressure measurements and a flow cytometric analysis of lymphocyte surface markers were performed. After 14 days, the animals were euthanized under anesthesia with ylazine/ketaniine.RESULTS:
Systolic BP progressively and significantly increased in rats 4th Ang II chronic infusion. We observed a statistical significant difference (p = 0.00001), in terms of T lymphocytes percentage between control rats plasma and Ang H treated rats lasma, in 14 days.CONCLUSIONS:
Angiotensin II is an important mediator of hypertension and directly promotes inflammation by noticeably increasing the quantity of T cells in kidney tissue.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Renina-Angiotensina
/
Vasoconstritores
/
Angiotensina II
/
Hipertensão
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article