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Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt-jakob disease: An international study.
McGuire, Lynne I; Poleggi, Anna; Poggiolini, Ilaria; Suardi, Silvia; Grznarova, Katarina; Shi, Song; de Vil, Bart; Sarros, Shannon; Satoh, Katsuya; Cheng, Keding; Cramm, Maria; Fairfoul, Graham; Schmitz, Matthias; Zerr, Inga; Cras, Patrick; Equestre, Michele; Tagliavini, Fabrizio; Atarashi, Ryuichiro; Knox, David; Collins, Steven; Haïk, Stéphane; Parchi, Piero; Pocchiari, Maurizio; Green, Alison.
Afiliação
  • McGuire LI; National CJD Research & Surveillance Unit, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
  • Poleggi A; Department of Neurological Sciences, National Institute of Health, Rome, Italy.
  • Poggiolini I; Institute of Neurological Sciences, Scientific Institute for Research, Hospitalization and Health Care, Bologna, Italy.
  • Suardi S; Department of Neurodegenerative Diseases, Scientific Institute for Research, Hospitalization and Health Care, Carlo Besta Neurological Institute, Milan, Italy.
  • Grznarova K; Sorbonne Universities, Pierre and Marie Curie University, Brain and Spine Institute, Paris, France.
  • Shi S; National Reference Centre for Unconventional Transmissible Agents, Paris, France.
  • de Vil B; Center for Neuropathology and Prion Research, Ludwig Maximilian University, Munich, Germany.
  • Sarros S; Department of Neurology, Institute of Born Bunge, University of Antwerp, Antwerp, Belgium.
  • Satoh K; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
  • Cheng K; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Cramm M; Prion Laboratory Section, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
  • Fairfoul G; Department of Neurology, University Medical Center and German Center for Neurodegenerative Diseases, University of Göttingen, Göttingen, Germany.
  • Schmitz M; National CJD Research & Surveillance Unit, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
  • Zerr I; Department of Neurology, University Medical Center and German Center for Neurodegenerative Diseases, University of Göttingen, Göttingen, Germany.
  • Cras P; Department of Neurology, University Medical Center and German Center for Neurodegenerative Diseases, University of Göttingen, Göttingen, Germany.
  • Equestre M; Department of Neurology, Institute of Born Bunge, University of Antwerp, Antwerp, Belgium.
  • Tagliavini F; Department of Neurological Sciences, National Institute of Health, Rome, Italy.
  • Atarashi R; Department of Neurodegenerative Diseases, Scientific Institute for Research, Hospitalization and Health Care, Carlo Besta Neurological Institute, Milan, Italy.
  • Knox D; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Collins S; Prion Laboratory Section, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
  • Haïk S; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
  • Parchi P; Sorbonne Universities, Pierre and Marie Curie University, Brain and Spine Institute, Paris, France.
  • Pocchiari M; National Reference Centre for Unconventional Transmissible Agents, Paris, France.
  • Green A; APHP, Pitié-Salpêtrière Hospital, Paris, France.
Ann Neurol ; 80(1): 160-5, 2016 07.
Article em En | MEDLINE | ID: mdl-27130376
ABSTRACT
Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt-Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT-QuIC is a suitably reliable and robust technique for clinical practice. Ann Neurol 2016;80160-165.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Creutzfeldt-Jakob / Agregação Patológica de Proteínas Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Creutzfeldt-Jakob / Agregação Patológica de Proteínas Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article