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SAbPred: a structure-based antibody prediction server.
Dunbar, James; Krawczyk, Konrad; Leem, Jinwoo; Marks, Claire; Nowak, Jaroslaw; Regep, Cristian; Georges, Guy; Kelm, Sebastian; Popovic, Bojana; Deane, Charlotte M.
Afiliação
  • Dunbar J; Department of Statistics, Oxford Protein Informatics Group, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Nonnenwald 2, 82377, Penzberg, Germany.
  • Krawczyk K; Department of Statistics, Oxford Protein Informatics Group, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK.
  • Leem J; Department of Statistics, Oxford Protein Informatics Group, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK.
  • Marks C; Department of Statistics, Oxford Protein Informatics Group, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK.
  • Nowak J; Department of Statistics, Oxford Protein Informatics Group, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK.
  • Regep C; Department of Statistics, Oxford Protein Informatics Group, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK.
  • Georges G; Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Nonnenwald 2, 82377, Penzberg, Germany.
  • Kelm S; Informatics Department, UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK.
  • Popovic B; Antibody Discovery and Protein Engineering, Medimmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.
  • Deane CM; Department of Statistics, Oxford Protein Informatics Group, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK deane@stats.ox.ac.uk.
Nucleic Acids Res ; 44(W1): W474-8, 2016 07 08.
Article em En | MEDLINE | ID: mdl-27131379
ABSTRACT
SAbPred is a server that makes predictions of the properties of antibodies focusing on their structures. Antibody informatics tools can help improve our understanding of immune responses to disease and aid in the design and engineering of therapeutic molecules. SAbPred is a single platform containing multiple applications which can number and align sequences; automatically generate antibody variable fragment homology models; annotate such models with estimated accuracy alongside sequence and structural properties including potential developability issues; predict paratope residues; and predict epitope patches on protein antigens. The server is available at http//opig.stats.ox.ac.uk/webapps/sabpred.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Internet / Anticorpos Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Internet / Anticorpos Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article