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Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Chen, Hongming; Tucker, Julie; Wang, Xiaotao; Gavine, Paul R; Phillips, Chris; Augustin, Martin A; Schreiner, Patrick; Steinbacher, Stefan; Preston, Marian; Ogg, Derek.
Afiliação
  • Chen H; Chemistry Innovation Centre, Discovery Sciences, AstraZeneca R&D Mölndal, 431 83 Mölndal, Sweden.
  • Tucker J; Structure and Biophysics, Discovery Sciences, AstraZeneca R&D Alderley Park, Macclesfield SK10 4TG, England.
  • Wang X; Innovation Centre China, AstraZeneca Asia and Emerging Markets iMed, Shanghai 201203, People's Republic of China.
  • Gavine PR; Innovation Centre China, AstraZeneca Asia and Emerging Markets iMed, Shanghai 201203, People's Republic of China.
  • Phillips C; Structure and Biophysics, Discovery Sciences, AstraZeneca R&D Alderley Park, Macclesfield SK10 4TG, England.
  • Augustin MA; Proteros biostructures GmbH, Bunsenstrasse 7a, 82152 Martinsried, Germany.
  • Schreiner P; Proteros biostructures GmbH, Bunsenstrasse 7a, 82152 Martinsried, Germany.
  • Steinbacher S; Proteros biostructures GmbH, Bunsenstrasse 7a, 82152 Martinsried, Germany.
  • Preston M; Screening Sciences, Discovery Sciences, AstraZeneca R&D Alderley Park, Macclesfield SK10 4TG, England.
  • Ogg D; Structure and Biophysics, Discovery Sciences, AstraZeneca R&D Alderley Park, Macclesfield SK10 4TG, England.
Acta Crystallogr D Struct Biol ; 72(Pt 5): 682-93, 2016 05.
Article em En | MEDLINE | ID: mdl-27139631
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Quinase 7 Ativada por Mitógeno / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Quinase 7 Ativada por Mitógeno / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article