Life-course blood pressure in relation to brain volumes.
Alzheimers Dement
; 12(8): 890-9, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27139841
ABSTRACT
INTRODUCTION:
The impact of blood pressure on brain volumes may be time-dependent or pattern-dependent.METHODS:
Of 1678 participants from the Atherosclerosis Risk in Communities Neurocognitive Study, we quantified the association between measures and patterns of blood pressure over three time points (â¼24 or â¼15 years prior and concurrent with neuroimaging) with late life brain volumes.RESULTS:
Higher diastolic blood pressure â¼24 years prior, higher systolic and pulse pressure â¼15 years prior, and consistently elevated or rising systolic blood pressure from â¼15 years prior to concurrent with neuroimaging, but not blood pressures measured concurrent with neuroimaging, were associated with smaller volumes. The pattern of hypertension â¼15 years prior and hypotension concurrent with neuroimaging was associated with smaller volumes in regions preferentially affected by Alzheimer's disease (e.g., hippocampus -0.27 standard units, 95% CI -0.51, -0.03).DISCUSSION:
Hypertension 15 to 24 years prior is relevant to current brain volumes. Hypertension followed by hypotension appears particularly detrimental.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Encéfalo
/
Envelhecimento
/
Aterosclerose
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article