Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb.

Yang, Jian-Bo; Li, Li; Dai, Zhong; Wu, Yu; Geng, Xing-Chao; Li, Bo; Ma, Shuang-Cheng; Wang, Ai-Guo; Su, Ya-Lun

Yang, Jian-Bo; Li, Li; Dai, Zhong; Wu, Yu; Geng, Xing-Chao; Li, Bo; Ma, Shuang-Cheng; Wang, Ai-Guo; Su, Ya-Lun.

Afiliação

Yang JB; a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Li L; b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.
Dai Z; c School of Chinese Pharmacy , Beijing University of Chinese Medicine , Beijing 100102 , China.
Wu Y; a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Geng XC; b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.
Li B; b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.
Ma SC; b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.
Wang AG; b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.
Su YL; b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China.

J Asian Nat Prod Res ; 18(9): 813-22, 2016 Sep.

Article em En | MEDLINE | ID: mdl-27139982

RESUMO

Four new dianthrone glycosides, named polygonumnolides C1-C4 (1-4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5-6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1-4 showed weak hepatotoxicity against L-02 cell lines with IC50 values of 313.05, 205.20, 294.20, and 207.35 µM, respectively.

Assuntos

Antracenos/isolamento & purificação; Medicamentos de Ervas Chinesas/isolamento & purificação; Glicosídeos/isolamento & purificação; Fígado/efeitos dos fármacos; Polygonum/química; Antracenos/química; Medicamentos de Ervas Chinesas/química; Medicamentos de Ervas Chinesas/farmacologia; Emodina/química; Glicosídeos/química; Humanos; Estrutura Molecular; Ressonância Magnética Nuclear Biomolecular; Raízes de Plantas/química; Estereoisomerismo

Palavras-chave

L-02 cell lines; Polygonum multiflorum; dianthrone glycosides; polygonumnolides C1C4

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Polygonum / Glicosídeos / Fígado / Antracenos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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