Design of structurally distinct proteins using strategies inspired by evolution.

Jacobs, T M; Williams, B; Williams, T; Xu, X; Eletsky, A; Federizon, J F; Szyperski, T; Kuhlman, B

Jacobs, T M; Williams, B; Williams, T; Xu, X; Eletsky, A; Federizon, J F; Szyperski, T; Kuhlman, B.

Afiliação

Jacobs TM; Program in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Williams B; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Williams T; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Xu X; Department of Chemistry, State University of New York at Buffalo, Buffalo, NY 14260, USA. Northeast Structural Genomics Consortium.
Eletsky A; Department of Chemistry, State University of New York at Buffalo, Buffalo, NY 14260, USA. Northeast Structural Genomics Consortium.
Federizon JF; Department of Chemistry, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Szyperski T; Department of Chemistry, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Kuhlman B; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. bkuhlman@email.unc.edu.

Science ; 352(6286): 687-90, 2016 May 06.

Article em En | MEDLINE | ID: mdl-27151863

Assuntos

Simulação por Computador; Modelos Químicos; Engenharia de Proteínas/métodos; Proteínas/química; Proteínas/genética; Evolução Biológica; Cristalografia por Raios X; Espectroscopia de Ressonância Magnética; Estrutura Secundária de Proteína

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Engenharia de Proteínas / Proteínas / Modelos Químicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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