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Serum miR-1297: a promising diagnostic biomarker in esophageal squamous cell carcinoma.
Wang, Cong; Li, Qingbao; Liu, Fang; Chen, Xuan; Nesa, Effat Un; Guan, Shanghui; Liu, Bowen; Han, Lihui; Tan, Bingxu; Wang, Ding; Chen, Pengxiang; Liu, Xiaoyue; Zhang, Han; Sun, Ying; Cheng, Yufeng.
Afiliação
  • Wang C; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Li Q; b Department of Cardiac Surgery , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , Shandong , People's Republic of China ;
  • Liu F; c Department of Imaging , Shandong Medical College , Jinan , Shandong , People's Republic of China ;
  • Chen X; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Nesa EU; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Guan S; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Liu B; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Han L; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Tan B; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Wang D; d Department of Clinical Laboratory , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China.
  • Chen P; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Liu X; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Zhang H; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Sun Y; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
  • Cheng Y; a Department of Radiation Oncology , Qilu Hospital of Shandong University , Jinan , Shandong , People's Republic of China ;
Biomarkers ; 21(6): 517-22, 2016 Sep.
Article em En | MEDLINE | ID: mdl-27152453
ABSTRACT
We aimed to value the diagnostic potential of serum miR-1297 in esophageal squamous cell cancer (ESCC). Its expression level was detected in 156 pairs of patients with ESCC and healthy volunteers using quantitative real-time polymerase chain reaction (qRT-PCR) method. It was statistically decreased in ESCC patients compared with healthy controls. AUC based on serum miR-1297 was 0.840 ± 0.035 in discovery group and 0.837 ± 0.034 in validation group. Further analysis on early-stage patients revealed that the AUC was 0.819 ± 0.053 in discovery group and 0.814 ± 0.044 in validation group. Its sensitivity and specificity were promising. In conclusion, serum miR-1297 can serve as an ideal indicator for the diagnosis of ESCC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Biomarcadores Tumorais / MicroRNAs Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Biomarcadores Tumorais / MicroRNAs Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article