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Review: adiponectin in retinopathy.
Fu, Zhongjie; Gong, Yan; Löfqvist, Chatarina; Hellström, Ann; Smith, Lois E H.
Afiliação
  • Fu Z; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  • Gong Y; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  • Löfqvist C; Department of Ophthalmology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Hellström A; Department of Ophthalmology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Smith LE; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: lois.smith@childrens.harvard.edu.
Biochim Biophys Acta ; 1862(8): 1392-400, 2016 08.
Article em En | MEDLINE | ID: mdl-27155572
Neovascular eye diseases are a major cause of blindness including retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration in which new vessel formation is driven by hypoxia or metabolic abnormalities affecting the fuel supply. White-adipose-tissue derived adipokines such as adiponectin modulate metabolic responses. Increasing evidence shows that lack of adiponectin may result in retinal neovascularization. Activation of the adiponectin pathway may in turn restore energy metabolism, to suppress the drive for compensatory but ultimately pathological neovessels of retinopathy. In this review, we will summarize our current knowledge of the role of adiponectin in eye diseases of premature infants, diabetic patients as well as the elderly. Further investigations in this field are likely to lead to new preventative approaches for these diseases.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neovascularização Retiniana / Retinopatia Diabética / Metabolismo Energético / Adiponectina Limite: Aged / Aged80 / Animals / Humans / Infant / Newborn Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neovascularização Retiniana / Retinopatia Diabética / Metabolismo Energético / Adiponectina Limite: Aged / Aged80 / Animals / Humans / Infant / Newborn Idioma: En Ano de publicação: 2016 Tipo de documento: Article